The disease is first apparent on the hips; later the entire thigh is affected. If folds of fat develop on the inner sides of the knees, inflammation can occur through rubbing.
Stage 1:
"Orange peel skin" or cellulitis, skin surface finely nodular
Stage 2:
"Mattress skin", coarsely nodular with larger dimples
Stage 3:
Large, deforming folds of fat
Advanced lipoedema impedes the drainage of blood through the veins and also the drainage of lymph into the lymphatic system. Therefore lymphoedema sometimes develops as a result of lipoedema. Experts then talk of lipo-lymphoedema. It is treated in the same way as lymphoedema.

Lipoedema
Course of the illness
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